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             ANTIBIOTICS  Macrolide: Macrolide antibiotics are produced by various strains of streptomyces. they have 3 common chemical characteristics. ✓ a large non-planar strain less ring. ✓ a keto group. ✓ a glycosidically linked amino sugar. Erythromycin Clarithromycin Azitromycin*                        ✓ Erythromycin, clarithromycin & Azitromycin comes under macrolides. ✓ All Macrolide Antibiotics have Lactone structures. ✓ Usually lactone ring has 12,14 or 16 atoms in it. STRUCTURE OF LACTONE: Erythromycin, clarithromycin & Azitromycin are similar in structure with small differences because of their 14&15 membered ring macrolides and also in placing of glucone moiety at 3 rd and 5 th positions . ERYTHROMYCIN: In erythromycin Hydrogen atoms in the OH group of 3rd and 5th positions is substituted with glucone moiety . 3rd position-OCH3       •  5th po...